Journal: Signal Transduction and Targeted Therapy
Article Title: Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route
doi: 10.1038/s41392-021-00848-1
Figure Lengend Snippet: Binding affinities of RBD mutants to hACE2 and mACE2. a – f The binding affinities of different RBD or S1 mutants to hACE2 and mACE2 were measured by surface plasmon resonance (SPR) assays with a Biacore TM T100 instrument. The K a , K d , and K D values were measured and calculated by the software BIAevaluation. The K D value shown was a mean of three independent experiments. These different RBD or S1 mutants included original RBD ( a ), S1 (D614G) ( b ), S1 (B.1.1.7) ( c ), RBD (K417N, E484K, N501Y) ( d ), RBD (K417T, E484K, N501Y) ( e ), and RBD (L452R, E484Q) ( f )
Article Snippet: Fig. 2 Binding affinities of RBD mutants to hACE2 and mACE2. a – f The binding affinities of different RBD or S1 mutants to hACE2 and mACE2 were measured by surface plasmon resonance (SPR) assays with a Biacore TM T100 instrument.
Techniques: Binding Assay, SPR Assay, Software